Creatinine Clearance (CrCl) Calculator

How to calculate Creatinine Clearance?

Creatinine clearance (CrCl) is a clinical measurement used to estimate the glomerular filtration rate (GFR). It reflects the rate at which the kidneys filter creatinine, a waste product from muscle metabolism, from the blood for excretion in urine.

The Cockcroft-Gault Formula:

CrCl = ((140 - Age) × Weight in kg) / (72 × Serum Creatinine in mg/dL)

For female patients, the final result is multiplied by 0.85 to account for generally lower muscle mass.

Using the CrCl calculator: an example

Let's look at a 60-year-old male patient who weighs 80kg and has a serum creatinine level of 1.2 mg/dL:

1. Subtract age from 140: 140 - 60 = 80
2. Multiply by weight: 80 × 80 kg = 6,400
3. Divide by (72 × creatinine): 6,400 / (72 × 1.2) = 6,400 / 86.4 = 74.07 mL/min
4. Apply sex coefficient: As a male, the coefficient is 1.0 (no change), resulting in a CrCl of 74.07 mL/min.

Medical Disclaimer

These results are mathematical estimates based on standard formulas and are for educational purposes only. They are not a substitute for professional medical judgment, diagnosis, or lab-verified GFR tests. Always consult with a healthcare professional before making clinical decisions.

Frequently Asked Questions

• What is a normal CrCl range? For healthy adults, a normal creatinine clearance range is generally 97 to 137 mL/min for males and 88 to 128 mL/min for females.
• Why does sex matter in this calculation? The formula accounts for sex because biological males typically have a higher muscle mass percentage than biological females, leading to higher baseline creatinine production.
• When should I see a doctor? If your calculated result is consistently below 60 mL/min, you should consult a doctor, as this can be a sign of chronic kidney disease (CKD).